Living With Corneal Swelling?

Learn about the ASTRA clinical study evaluating an investigational therapy for corneal edema caused by corneal endothelial dysfunction.

Corneal swelling can make vision blurry, hazy, or inconsistent. This clinical study is evaluating whether an investigational therapy may have the potential to help.

Living With Corneal Swelling?

Learn about the ASTRA clinical study evaluating an investigational therapy for corneal edema caused by corneal endothelial dysfunction.

Corneal swelling can make vision blurry, hazy, or inconsistent. This clinical study is evaluating whether an investigational therapy may have the potential to help.

What Is Corneal Endothelial Dysfunction?  

The cornea depends on functional endothelial cells to stay compact and clear. When these cells stop working, fluid builds up inside the cornea. This fluid buildup causes corneal swelling (corneal edema), which can make vision blurry, hazy, or fluctuate during the day. Many people with this condition may eventually require a corneal transplant.

As fluid builds up in the cornea, it can change how light passes through the eye. This often affects vision in ways that may be noticeable during everyday activities.

People with corneal endothelial dysfunction may experience:

Cloudy, hazy, or foggy vision, especially in the morning
Vision that changes throughout the day, sometimes improving as the day goes on
Glare or halos around lights, particularly at night
Difficulty with activities such as reading, driving, or working on screens
Increased eye discomfort as the condition becomes more advanced

These vision changes can gradually interfere with daily life. For some people, standard treatment options may eventually include corneal transplant surgery.

As fluid builds up in the cornea, it can change how light passes through the eye. This often affects vision in ways that may be noticeable during everyday activities. People with corneal endothelial dysfunction may experience:

Cloudy, hazy, or foggy vision, especially in the morning

Vision that changes throughout the day, sometimes improving as the day goes on

Glare or halos around lights, particularly at night

Difficulty with activities such as reading, driving, or working on screens

Increased eye discomfort as the condition becomes more advanced

These vision changes can gradually interfere with daily life. For some people, standard treatment options may eventually include corneal transplant surgery.

People with corneal endothelial dysfunction may experience:

Cloudy, hazy, or foggy vision, especially in the morning
Vision that changes throughout the day, sometimes improving as the day goes on
Glare or halos around lights, particularly at night
Difficulty with activities such as reading, driving, or working on screens
Increased eye discomfort as the condition becomes more advanced

These vision changes can gradually interfere with daily life. For some people, standard treatment options may eventually include corneal transplant surgery.

About the ASTRA Study  

The ASTRA clinical study is evaluating AURN001, an investigational therapy for corneal swelling caused by corneal endothelial dysfunction. The purpose of the study is to evaluate its safety and to learn whether it may:

Replace diseased
endothelial cells

Restore normal Corneal
fluid balance

Reduce corneal
swelling

Improve clarity
and vision

Because AURN001 is investigational, results are still being studied and cannot be guaranteed.

Find a Study Doctor  

The ASTRA study is being conducted at selected ophthalmology centers. Study doctors can guide participants through screening and next steps.

Contact

If you want to learn more, you may contact the ASTRA study team.